According to the August 2010 Wellness Letter, “there is no convincing evidence that any ‘brain formula,’ plant extract, or vitamin will preserve memory.” However, a deficiency in B12 can cause confusion and memory loss. See your doctor for testing and treatment, if needed. Another supplement to consider is fish oil, which has been linked to a slowing of cognitive decline in healthy people. Currently, the results are mixed, but if the fish oil benefits your cardiovascular system, it may help your brain as well.